for assistance call: 1-888-673-3444
Happy World Rat Day!
April 4, 2023 is World Rat Day! The RRRC would like to acknowledge the important contributions to science and medicine made possible by the use of rats in biomedical research.
April 04, 2023
Exciting Job Opportunities
April 03, 2023
The RRRC is looking to expand its team! We have positions available in colony management, data curation, cryobiology, reproductive biology, and customer service. We are also looking for individuals interested in post-doctoral training with both a service and research emphasis. Interested in learning more? Contact Dr. Elizabeth Bryda at rrrc@missouri.edu.
NIH Extrinsic Factors Workshop
August 09, 2022
Enhance Rigor and Reproducibility in Animal Research by Managing Extrinsic Factors
When: September 23, 28, and 30, 2022
Venue: Zoom
Register: scgcorp.com/ExtrinsicFactorsWS
The workshop will be a forum to discuss the current status of and needs for understanding extrinsic environmental factors; their potential impact on animal research outcomes; and how facilities may optimally manage, monitor, and report these extrinsic factors in an effort to enhance reproducibility and rigor in animal research. The focus of this workshop will be on identifying gaps, opportunities, and new approaches in husbandry of commonly and widely used animal models; relevant environmental factors and conditions; and the need for novel instruments, equipment, and infrastructure for animal research core facilities (e.g., modern design of research core facilities, high-throughput equipment, telemetry for behavioral research).
Rats on the rise
July 20, 2021
Rats on the rise. Ellen P. Neff (Lab Animal, 2021). After a genetic revolution in the 80s, mice overtook rats as the laboratory animal of choice for many researchers. But in recent years, the gene editing capabilities that had lagged a little for the larger rodent have been coming up to par with their murine cousins. Is a return to rats on the way?
RRRC Fully Operational
June 14, 2020
The RRRC is fully operational at this time and we are excited to be able to assist researchers with all their rat-related needs. Publications
KSOM-R supports both mouse and rat preimplantation embryo development in vitro.
Men H, Amos-Landgraf JM, Bryda, EC, Franklin, CL. (2023) Theriogenology 198:69-74.
The Atg16l1 gene: characterization of wild type, knock-in, and knock-out phenotypes in rats. Chesney KL, Men H, Hankins MA, Bryda EC.(2021) Physiol Genomics. 53:269-281.
Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes. Men H, Hankins MA, Bock AS, Beaton BP, Davis DJ, Chesney KL, Bryda EC.(2021) Mamm Genome.32:173-182.
Media optimization to promote rat embryonic development to the blastocyst stage in vitro. Men H, Stone BJ, Bryda EC. (2020) Theriogenology 151:81-85.
A Non-surgical Embryo Transfer Protocol for Fresh and Cultured Blastocysts in Rats. Stone BJ, Steele KH, Men H, Srodulski SJ, Bryda, EC, Fath-Goodin, A. (2020) J Am Assoc Lab Anim Sci 59:488-495.
Using vaginal impedance measurement to stage estrous in rats given luteinizing hormone releasing hormone (LHRH) agonist. Chesney KL, Chang C, Bryda EC. (2020) J Am Assoc Lab Anim Sci 59:282-287.
A novel conditional ZsGreen-expressing transgenic reporter rat strain for validating Cre recombinase expression. Bryda EC, Men H, Davis DJ, Bock AS, Shaw ML, Chesney KL, Hankins MA. (2019) Scientific Reports 9:13330.
Letter to the editor announcing the availability of RCS and transgenic rats with P23H and S334ter rhodopsin mutations with inherited retinal degenerations. Bryda EC and LaVail M. (2019) Exp Eye Res. 178:176.
Rat Genome and Model Resources. Shimoyama M, Smith JR, Bryda E, Kuramoto T, Saba L, Dwinell M. (2017) ILAR Journal. 58:42–58.
Derivation of transgene-free rat induced pluripotent stem cells approximating the quality of ES cells. Li S, Lan H, Men H, Wu Y, Li N, Capecchi MR, Bryda EC, Wu S. (2017) Stem Cells Translational Medicine 6:340-351.
Efficient Generation of Selection-Gene-Free Rat Knockout Models by Homologous Recombination in ES Cells. Lan H, Li S, Guo Z, Men H, Wu Y, Li N, Bryda EC, Capecchi M, Wu S. (2016) FEBS Letters 590:3416-3424.
Rapid conditional ablation model for hemolytic anemia in the rat. Hanson MM, Liu F, Dai S, Kearns A, Qin X, Bryda EC. (2016) Physiological Genomics 48:626-632.
Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis. Hansen SA, Hart ML, Busi S, Parker T, Goerndt A, Jones K, Amos-Landgraf JM, Bryda EC. (2016) Dis Model Mech. 9(10):1139-1146.
Post-thaw ATP supplementation enhances cryoprotective effect of iodixanol in rat spermatozoa. Kim, S, Hooper, S, Agca, C, Agca, Y. (2016) Reprod Biol Endocrinol. 14:5.
Differential Susceptibility to Colorectal Cancer due to Naturally Occurring Gut Microbiota. Ericsson AC, Akter S, Hanson MM, Busi SB, Parker TW, Schehr RJ, Hankins MA, Ahner CE, Davis JW, Franklin CL, Amos-Landgraf JM, Bryda EC. (2015) Oncotarget 6:33689-33704.
Electroejaculation of chimeric rats. McCoy MR, Montonye D, Bryda EC. (2014) Lab Anim (NY) 42:203-5.
Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells. Bock AS, Leigh ND, Bryda EC. (2014) In Vitro Cell Dev Biol Anim.50:572-579.
Derivation of a Germline Competent Transgenic Fischer 344 Embryonic Stem Cell Line. Men, H and Bryda, EC. (2013) PLoS One 8:e56518.
Germline Transmisson of a Novel Rat Embryonic Stem Cell Line Derived from Transgenic rats. Men H. Bauer BA, Bryda EC. (2012) Stem Cells Dev. 21:2606-2612.
Changes in rat spermatozoa function after cooling, cryopreservation and centrifugation processes. Kim S, Agca C, Agca Y. (2012) Cryobiology. 65:215-223.
Effects of various physical stress factors on mitochondrial function and reactive oxygen species in rat spermatozoa. Kim S, Agca C, Agca Y. (2013) Reprod Fertil Dev. 25:1051-1064.
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