for assistance call: 1-888-673-3444
 
Weather Advisory
 February 16, 2025
Weather impacts shipments, particularly of live animals. Please check with your selected courier to learn how their shipping methods (e.g. air or ground shipment) and temperature restictions may impact your orders. While we recognize that shipping delays are frustrating, when it comes to live animal shipments, the safety and welfare of the animals comes first. 
In Need of a New Rat Model?
 February 16, 2025
Need a new rat model?  The RRRC in conjunction with the MU Animal Modeling Core (AMC) can assist with the generation of transgenic rats, create knock-out and knock-in rats using CRISPR/Cas9 technology and genetically manipulate rat embryonic stem cells to make chimeric animals.  Contact us to discuss your rat model needs and how we can help. 
Laboratory Animal Genetic Reporting (LAG-R) Guidelines Published
 July 07, 2024
The LAG-R framework (Laboratory Animal Genetic Reporting) is a set of guidelines to support more complete documentation of the genetic make-up of animals of all species that are used in research, with the aim of bolstering reproducibility, reliability, and overall scientific rigor. See Nature Communications (https://doi.org/10.1038/s41467-024-49439-y).
GRCr8: A new rat reference assembly is now available.
 February 05, 2024
GRCr8 (GenBank NCBI # GCA_036323735.1) is the latest version of the rat reference genome assembly. See the Genome Reference Consortium (GRC) blog for more details.
RRRC Publications
 
KSOM-R supports both mouse and rat preimplantation embryo development in vitro.
Men H, Amos-Landgraf JM, Bryda, EC, Franklin, CL. (2023) Theriogenology 198:69-74.

The Atg16l1 gene: characterization of wild type, knock-in, and knock-out phenotypes in rats. Chesney KL, Men H, Hankins MA, Bryda EC.(2021) Physiol Genomics 53:269-281.

Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes. Men H, Hankins MA, Bock AS, Beaton BP, Davis DJ, Chesney KL, Bryda EC.(2021) Mamm Genome.32:173-182.

Media optimization to promote rat embryonic development to the blastocyst stage in vitro.
Men H, Stone BJ, Bryda EC. (2020) Theriogenology 151:81-85.

A Non-surgical Embryo Transfer Protocol for Fresh and Cultured Blastocysts in Rats. Stone BJ, Steele KH, Men H, Srodulski SJ, Bryda, EC, Fath-Goodin, A. (2020) J Am Assoc Lab Anim Sci 59:488-495.

Using vaginal impedance measurement to stage estrous in rats given luteinizing hormone releasing hormone (LHRH) agonist. Chesney KL, Chang C, Bryda EC. (2020) J Am Assoc Lab Anim Sci 59:282-287.

A novel conditional ZsGreen-expressing transgenic reporter rat strain for validating Cre recombinase expression. Bryda EC, Men H, Davis DJ, Bock AS, Shaw ML, Chesney KL, Hankins MA. (2019) Scientific Reports 9:13330.

Letter to the editor announcing the availability of RCS and transgenic rats with P23H and S334ter rhodopsin mutations with inherited retinal degenerations. Bryda EC and LaVail M. (2019) Exp Eye Res. 178:176.

Rat Genome and Model Resources. Shimoyama M, Smith JR, Bryda E, Kuramoto T, Saba L, Dwinell M. (2017) ILAR Journal. 58:42–58.

Derivation of transgene-free rat induced pluripotent stem cells approximating the quality of ES cells. Li S, Lan H, Men H, Wu Y, Li N, Capecchi MR, Bryda EC, Wu S. (2017) Stem Cells Translational Medicine 6:340-351.

Efficient Generation of Selection-Gene-Free Rat Knockout Models by Homologous Recombination in ES Cells. Lan H, Li S, Guo Z, Men H, Wu Y, Li N, Bryda EC, Capecchi M, Wu S. (2016) FEBS Letters 590:3416-3424.

Rapid conditional ablation model for hemolytic anemia in the rat.
Hanson MM, Liu F, Dai S, Kearns A, Qin X, Bryda EC. (2016) Physiological Genomics 48:626-632.

Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis. Hansen SA, Hart ML, Busi S, Parker T, Goerndt A, Jones K, Amos-Landgraf JM, Bryda EC. (2016) Dis Model Mech. 9(10):1139-1146.

Post-thaw ATP supplementation enhances cryoprotective effect of iodixanol in rat spermatozoa. Kim, S, Hooper, S, Agca, C, Agca, Y. (2016) Reprod Biol Endocrinol. 14:5.

Differential Susceptibility to Colorectal Cancer due to Naturally Occurring Gut Microbiota.
Ericsson AC, Akter S, Hanson MM, Busi SB, Parker TW, Schehr RJ, Hankins MA, Ahner CE, Davis JW, Franklin CL, Amos-Landgraf JM, Bryda EC. (2015) Oncotarget 6:33689-33704.


Electroejaculation of chimeric rats. McCoy MR, Montonye D, Bryda EC. (2014) Lab Anim (NY) 42:203-5.

Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells. Bock AS, Leigh ND, Bryda EC. (2014) In Vitro Cell Dev Biol Anim.50:572-579.

Derivation of a Germline Competent Transgenic Fischer 344 Embryonic Stem Cell Line. Men, H and Bryda, EC. (2013) PLoS One 8:e56518.

Germline Transmisson of a Novel Rat Embryonic Stem Cell Line Derived from Transgenic rats. Men H. Bauer BA, Bryda EC. (2012) Stem Cells Dev. 21(14):2606-2612.

Changes in rat spermatozoa function after cooling, cryopreservation and centrifugation processes. Kim S, Agca C, Agca Y. (2012) Cryobiology.  65(3):215-223.