The RRRC can refine rat models by moving mutations or other genetic alterations onto a different genetic background or by taking strains with a mixed genetic background and backcrossing them onto one of the parental genetic backgrounds in order to decrease genetic variability. Our expertise in speed congenics allows us to accelerate this process.
Multiplex microsatellite marker panels for genetic monitoring of common rat strains. Bryda EC, Riley LK. (2008) Journal of the American Association for Laboratory Animal Science. 47(3):37-41.
Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis. Hansen SA, Hart ML, Busi S, Parker T, Goerndt A, Jones K, Amos-Landgraf JM, Bryda EC. (2016) Dis Model Mech. 9(10):1139-1146.
08.25.2025
Why Research Resource Identifiers (RRIDs) Are Important
RRIDs are unique identifiers for key biological resources, genetically enigineered animals and reagents like antibodies. Piekniewska et al. document how use of RRIDs improves trackability. Importantly, better citation practices increase research rigor and reproducibility.
07.30.2025
Animal Models and New Approach Methodologies (NAMs)
NAMs are lab (e.g., organoids and iPSCs) or computer-based methods intended to expand our tools for modeling human biology and disease. While this field is rapidly evolving, the need for animal models remains, especially for situations where a complex biological system is necessary. In addition, animal models serve as vital in vivo controls for the validation and verification of emerging NAMs.
05.17.2025
Weather and Shipping
The welfare of the animals is of utmost importance and as we head into the summer months, inclement weather and excessive heat will delay/prevent shipments of live animals. Be aware that hot temperatures between June and mid-September may negatively impact the ability of couriers to safely ship animals so please plan your live animal orders accordingly.
02.16.2025
In Need of a New Rat Model?
Need a new rat model? The RRRC in conjunction with the MU Animal Modeling Core (AMC) can assist with the generation of transgenic rats, create knock-out and knock-in rats using CRISPR/Cas9 technology and genetically manipulate rat embryonic stem cells to make chimeric animals. Contact us to discuss your rat model needs and how we can help.